 This study found that the core implementation strategy was not associated with improved adherence to the ADAPT clinical pathway compared to the enhanced implementation strategy. However, the enhanced implementation strategy was associated with better adherence among patients with lower levels of anxiety and depression. This suggests that tailoring implementation efforts to patient needs may be important when implementing new clinical pathways in busy healthcare settings. This article was authored by Philisputo, Mona M. Farris, Joanne Shaw, and others.