 Collagen is a structural protein found in connective tissues such as tendons. When subjected to high loads, it can undergo a process called mechanoradicals, which involves breaking down into smaller pieces. This process is similar to what happens when polymer chains break down. The location and type of initial rupture sites have a significant effect on how the tissue responds to stress. Using simulations and experiments, we identified the weakest bonds in collagen and found that they are located in trivalent cross-links. These bonds are more likely to break than the backbone of the collagen, allowing for the formation of mechanoradicals without compromising the overall structure of the tissue. Furthermore, the presence of these weak bonds helps to direct the rupture of the collagen fibers away from the more vulnerable areas, thus reducing the risk of catastrophic failure. This article was authored by Benedict Renicamp, Kristof Karfuser, Markus Korf, and others.