 Plant toxic proteins are secondary metabolites produced by plants to protect them from threats such as insects, predators, microorganisms, and environmental conditions. They include ribosome inactivating proteins, lectins, protease inhibitors, alpha amylase inhibitors, canotoxin-like proteins and ureazas, arsalins, antimicrobial peptides, and pore-forming toxins. These proteins have been studied extensively for their potential applications in agriculture, drug development, cancer treatment, and genetic engineering. Despite their beneficial properties, they can also be harmful if consumed in large quantities. This review discusses the biological activities and mechanisms of action of plant toxic proteins as well as their potential uses and removal strategies. This article was authored by Amin Kosaijit, Batol Kokadem Boskert, Osman Boskert, and others.