 Colorectal liver metastasis is a common form of cancer that can be difficult to treat due to its high rate of recurrence. Molecular biomarkers have been identified which may help guide the selection of individualized treatment options and predict patient outcomes. However, these markers are not always reliable or consistent across different studies, making it difficult to determine how best to use them in practice. It is therefore important to exercise caution when interpreting the results of any given study and to consider the implications of the findings before implementing them in clinical settings. This article was authored by Marcus K. Deener and Stefan Fickner-Fiegel.