 My work here is mainly focused on finding new mouse models for immune deficiency. So for humans that have usually relatively severe infections because the immune system isn't able to cope with viruses and bacteria that most of us have no problem with. And over the last probably 20, 30 years huge progress has been made in this area but still it is not really clear what genes what molecules are important for the cells of our immune system to really be developing in a way and being activated in a way that is provides an effective protection against infections. Our main experiment I'm only is that we take mice where we suspect that they have some defects in the immune system and immunize them will enter them similar to what is used in humans and then measure the response of these mice to the immunization. Then we look for those that don't have a normal response and try to investigate why they don't have it. If we find something there we then try to relate that back to humans by looking if similar genetic defects also occur in humans that have diseases of the immune system and the long-term aim of that is of course not only to understand why some humans have severe immunodeficiencies but also to come up with new strategies to protect those with severe immune defects or to design vaccines that specifically activate cellular processes that are important for generating good immune response and hopefully by doing that be able to develop vaccines against diseases where we can't do that at the moment. We've identified two new genes that were previously not known to be in any way important for the immune system and at the moment we're trying to really understand what these genes do and how they contribute to the normal function of the immune system and at the same time I'm now starting to work closely together with clinicians that look after patients with diseases caused by very similar genetic defects so we're looking in those patients if they have a defect in these previously not known gene and that is I think the plan for the next few years to really start more translating what I've built up here in the last five six years.