 The aim of this study was to assess the efficacy of intralesional metronidazole on Leishmania donovani cutaneous leishmaniasis, C.L. A total of 188 patients were randomly allocated to intralesional sodium cybogluconate, SSG, and intralesional metronidazole. The results showed that intralesional SSG had a higher cure rate than intralesional metronidazole, with statistical significance at P less than 0.05 level when the treatment cutoff was taken at 100% or above 80%. The study concluded that intralesional SSG is the best response against C.L., while intralesional metronidazole is an effective alternative treatment. This article was authored by Vihani and Somaratni, Ranthalaka Aranawaka, H.M. Jairuwin, and others.