 This study examined human and cat rabies cases in Brazil between 1986 and 2022. It found that most cases were caused by the AGV-3 variant of the virus, which was transmitted primarily from bats. Additionally, it identified a high incidence of cat rabies cases, which was attributed to the animal's tendency to hunt and their close proximity to humans. Finally, the study highlighted the importance of animal hoarding and rescuer behaviors as potential sources of transmission. This article was authored by Jonathan Santos de Lima, Enio Mori, Luiz Bach, Mediac, and others.