 This study explored the genetic cause of autosomal recessive retinitis pigmentosa in consanguinous families. It found that a mutation in the PDE6-A gene was responsible for the disease, which was identified through linkage analysis, Sanger sequencing, and bioinformatics tools. This mutation was also found to be homozygous in 7 of the 80 families studied, suggesting that it could be a major contributing factor to the disease. Furthermore, this study offers valuable information regarding genetic counseling and disease prevention in consanguinous families. This article was authored by Anusha Ali Khan, your Muhammad warrior, Muhammad Iqbal, and others.