 This study investigated the prevalence of erythromycin and erythromycin induced resistance to clindamycin among Staphylococcus aureus, S aureus. It also assessed for potential inhibitors of this resistance. The results showed that 39.6 percent of the isolates had constitutive MLSB resistance, 14.3 percent had inducible MLSB resistance, and 2.2 percent had macrolide streptochromin, MS, resistance. Genes such as ERMC, ERMA, ERMB, MSRA, MSRB, LNUA, and MPHC were found in 82.6 percent, 5.8 percent, 7.7 percent, 3.8 percent, 3.8 percent, 13.5 percent, and 3.8 percent of isolates, respectively. Additionally, erythromycin resistance was significantly reduced by doxorubicin, neomycin, and omeprazole. Quinine, ketoprophin, and phosphamycin combated and reversed erythromycin slash clindamycin induced resistance. This article was authored by Aya Amafuz, Hiba S. Said, Sharon Amalfiqi, and others.