 The study aimed to investigate the neurophysiological correlations of multiple sclerosis MS, symptoms by probing corticospinal tract integrity using transcranial magnetic stimulation, TMS. The results show that PWMS differed from non-clinical samples in MEP latency for upper and lower extremity muscles, and that altered MEP latency was associated with higher EDSS functional scores. TMS slash MEP latency findings classified PWMS as the same as EDSS functional pyramidal scores in 70 to 83 percent of cases and were similar to the MRI results in 57 to 65 percent of cases. The study provides preliminary evidence on the correspondence of MRI and TMS corticospinal tract evaluation results with EDSS functional pyramidal score results in MS. This article was authored by Maya Rajikvidikovic, Anakar Kovic-Kaddik, Sonda Pavlin, and others.