 This study aimed to identify attributes and facilitators for a comprehensive vaccine intervention in OBGYN clinical settings by conducting in-depth interviews with 24 providers from urban and suburban practices in Georgia and Colorado about their immunization attitudes, practices, and patient experiences. Six major themes emerged, strong provider buy-in for maternal immunization, the supporting role of clinical, interpersonal cues for vaccine promotion, varying provider patient communication approaches, an urgent need for a designated office immunization champion, reimbursement and practice implementation challenges, and region differences in attitudes toward maternal immunization. The findings reflect needs for immunization champion identification, training, and support, along with best practices guidelines to improve coordination of vaccine promotion and delivery efforts in OBGYN provider offices. Provider training on communication approaches to enhance acceptance and uptake of maternal vaccines is also warranted.