 This research explored the experiences of Iranian housewives with musculoskeletal disorders and developed a comprehensive behavior change framework to facilitate implementing a musculoskeletal health-promoting training intervention for women. The study found that the prevalence of musculoskeletal disorders among Iranian housewives is particularly high due to the physical demands of their daily activities. The study also identified individual and social predictors of musculoskeletal disorders and their control, risk factors for musculoskeletal disorders and prevention and treatment of musculoskeletal disorders. The study concluded that ecological models, such as the theory of triadic influence, can be useful in supporting the development and implementation of multidisciplinary interventions to improve the quality of life of housewives. This article was authored by Salman Anaruzi, Sediqas Adat to Vafian, Rosanna Cousins, and others.