Kidney Song





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Published on Dec 11, 2011

Studying for finals...I thought this was the best way.
Instrumental taken from MMPPP


Renal function starts right at our two kidneys
Located in the back of our abdominal wall
Excretes and regulates what stays in and out
And contains very important endocrine glands

Endocrine glands they regulate
EPO, rennin and Vitamin D
Kidneys also participate in gluconeogenesis

Regulating our water concentration
Processing plasma portions of our blood
Out go metabolic wastes like urea, uric acid and creatinine
Through the urine go the foreign chemicals:
Pesticides, drugs, additives, metabolites
Off to the bladder our urine goes
Through the urethra it gets disposed

Blood enters the glomerulus then the bowman's space
Where it separates into 3 filtrated layers
Then goes through the efferent arteriole and then the proximal tubule
Flowing into the Henle loop, which contains the macula densa
Passing we see juxtaglomerular cells on the afferent arteriole

Glomerular filtrate is now cell free, contains all substances except protein
Then there's tubular secretion, from peritubular plasma to the lumen
Can't forget our tubular reabsorption,
Moving from tubular lumen to peritubular capillary plasma
Out it goes hurrah!

Filtration pathways are negatively charged
Substances bound to plasma aren't filterable
Glomerular force is determined by hydrostastic and osmotic pressures
By glomerular capillaries and Bowman's capsule
The filtration rate is directly proportional
To membrane permeability
And it's surface area
Rate is regulated by hormonal input
And by the neural input to the two
Afferent and efferent arterioles
Providing net changes in GF pressures
If you constrict efferent arterioles
You increase capillary hyrdostratic pressures
In glomerular capillaries
However if you constrict the afferent ones
Those pressures now automatically decrease
And mesangial cells surround glomerular capillaries
If they contract they reduce the Glomerular filtration rate and surface area

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