 endolicins are bacteriophage, phage-encoded enzymes that can specifically hydrolyze the bacterial cell wall and quickly kill bacteria. They have been shown to be effective against many types of gram-positive bacteria, including methicillin-resistant Staphylococcus aureus MRSA. Due to their low resistance rate, endolicins are considered promising alternatives for treating gram-positive bacterial infections. This review summarizes the structure, mechanism, efficacy, and advantages of endolicins as antibacterial drug candidates. It also discusses the potential of phage endolicins in the treatment of gram-positive bacterial infections. This article was authored by Hiliu, Chen Hu, Meng Yang Li, and others.