 Monkeypox is a zoonotic disease caused by an orthopox virus that results in a small pox-like disease in humans. Since its initial diagnosis in 1970 in the Democratic Republic of the Congo, DRC, it has spread to other regions of Africa and cases outside Africa have emerged in recent years. The number of human monkeypox cases has been on the rise since the 1970s, with the most dramatic increases occurring in the DRC. The median age at presentation has increased from 4, 1970s to 21 years, 2010 to 2019. There was an overall case fatality rate of 8.7%, with a significant difference between clade central African 10.6%, 95% CI, 8.4% to 13.3%, versus West African 3.6%, 95% CI, 1.7% to 6.8%. Since 2003, import and travel-related spread outside of Africa has occasionally resulted in outbreaks. Interactions slash activities with infected animals or individuals are risk behaviors associated with acquiring monkeypox. The appearance of outbreaks beyond Africa highlights the global relevance of the disease. Increased surveillance and detection of monkeypox cases are essential tools for understanding the continuously changing epidemiology of this resurgent disease. This article was authored by Evelyn M. Bunch, Bernard Hote, Lydia Chan, and others. We are article.tv, links in the description below.