 This study found that biennial mammography screening for women aged 45 to 70 years in urban China is cost-effective when compared to no screening. The model estimated that the discounted Acer was $17,309 per LIG, indicating that the benefits outweigh the costs. Additionally, the model showed that over a 10-year period, screening would incur a net cost of approximately $38.1 million for a city with 1 million citizens.