 Three nanocomplexes of Cu, II, Co, II, and Ni, II with theophyllin were synthesized by ultrasonic sonication method, resulting in smaller and narrow-distributed nanoparticles without aggregations. The synthesized nanocomplexes were identified and suggested their structure using melting point, molar conductivity, solubility, flame atomic absorption, Fourier transform infrared spectroscopy, FTIR, and elemental analysis C, H, N, and S. The transmission electron microscopy, TM, results showed that the size of nanocomplexes was in the range of 15 to 25 nanometers. All synthesized nanocomplexes had very high susceptibility to inhibit bacterial growth with the copper nanocomplex giving the highest inhibition zone for each type of bacterial strains due to surface plasmon. The copper nanocomplex was converted into cream and found to have a potent influence in healing skin injuries on laboratory mice. This article was authored by Ahmad Hussein Ismail, Hassanine Kamal Al-Bermany, Zainab Sabri Abbas, and others. We are article.tv, links in the description below.