 This study analyzed population-based data from the SEER database, 2010 to 2013, to investigate the clinical correlates and prognostic value of distant metastatic sites among patients with cutaneous melanoma. The results showed that patients with isolated skin or subcutaneous metastases had the best overall and melanoma-specific survival, while those with isolated liver, bone, or brain metastases had the worst survival. Multivariate analysis revealed that age over 70, multiple sites of metastases, no surgery to the primary tumor, and no surgery to the metastatic disease were associated with worse overall survival. For melanoma-specific survival, nodal positivity, multiple sites of metastases, no surgery to the primary tumor, and no surgery to the metastatic disease were associated with worse survival. The study highlights the importance of considering the site of distant metastases, when managing metastatic cutaneous melanoma, and suggests that further prospective studies are needed to evaluate the role of local treatment in the management of metastatic disease. This article was authored by Omar Abdel Rahman. We are article.tv, links in the description below.