 Collagen is a protein found throughout the human body, making it an ideal material for tissue engineering applications. It is readily available, biodegradable, biocompatible, and can be easily modified to meet specific needs. Despite these advantages, sterilization of collagen-based materials can be challenging due to their protein nature. This review provides an overview of the various applications of collagen-based biomaterials used in tissue engineering, including their potential for use in regenerative medicine. This article was authored by François Berthaud, Robert Govan, and Remy Parenta-Barrell.