 In Madurai, India, there was a 30% increase in all cause deaths compared to what would have been expected based on previous years. This increase was largely due to deaths caused by cardiovascular and cerebrovascular conditions, diabetes, senility, and other unspecified causes. However, this increase was also accompanied by a spike in deaths attributed to COVID-19, suggesting that many of the unexplained deaths may be due to undocumented cases of the virus. The implementation of lockdown measures was associated with a decrease in deaths attributed to injuries, infectious diseases, and maternal conditions, while increasing deaths attributed to cancer. These results suggest that the COVID-19 pandemic has had a significant impact on overall mortality rates in Madurai, India, and that further research should be done to better understand the underlying causes of these deaths. This article was authored by Joseph A. Unid, Chandra Mohan B., Gogandikang, and others.