 The COVID-19 pandemic has caused a large infected population worldwide, prompting the urgent need for a rapid and simple diagnostic method to detect SARS-CoV-2. We developed a reverse transcription loop-mediated isothermal amplification, RT-Lamp, method that can detect SARS-CoV-2 in 30 minutes, using four sets of lamp primers targeting the viral RNA in ORF1ib, S-gene, and N-gene. The results are reported by a colorometric change that can be read by the naked eye, without expensive or dedicated instruments. The sensitivity is 80 copies of viral RNA per ML in a sample, and we validated the method in a hospital in China with consistent results compared to conventional RTQ PCR. Our one-step process without RNA extraction is feasible for direct RNA amplification from a sample, making it suitable for large screening at public domains and hospitals, particularly regional hospitals and medical centers in rural areas. This article was authored by Wei Yi Huan, Boon Lim, Chia Chen Su, and others. We are article.tv, links in the description below.