 This study found that 15 to 70 percent of urinary stone disease, USD, is caused by urinary tract infections, UTIs, which are often caused by multi-drug resistant, MDR, bacteria such as Staphylococcus aureus ATCC43300. These bacteria can enhance the formation of Stravite stones in diabetic patients with UTIs and hyperglycemia, protonuria, and using of metformin drug may be important factors. The study used experimental design of Taguchi method to determine optimal levels of glucose, metformin, and protein for the formation of Stravite stones in artificial urine medium. Results showed that highest concentration of Stravite stones, 0.512G-L, was obtained under interaction conditions of 3 by 2 by 2 levels respectively for glucose, metformin, and protein. SEM and EDAX analyses revealed clumped crystallite property and flower-like nanocomposites, NCs, of Stravite stones with contribution of calcium, 160.8, and phosphate, 131.4 elements. The study concluded that therapy of MDR bacteria, hyperglycemia, and protonuria can decrease urinary stone formation in diabetic patients by having UTIs. This article was authored by Nadia Asadi, Mojtaba Turan, Miriam Rad, and others. We are article.tv, links in the description below.