 The normal function of the medial prefrontal cortex MPFC is essential for regulating neurocognition, but it is disrupted in the early stages of Alzheimer's disease AD. Despite this, little is known about how the functional activity of medial prefrontal cortex pyramidal neurons changes as AD progresses during aging. We used electrophysiological techniques, patch clamping, to assess the functional activity of medial prefrontal cortex pyramidal neurons in the brain of 3XTG, Alzheimer's disease mice modeling early stage Alzheimer's disease without A-beta accumulation. Our results indicate that firing rate and the frequency of spontaneous excitatory post-synaptic currents, SCPSCs, were significantly increased in medial prefrontal cortex neurons from young Alzheimer's disease mice, 4 to 5 months, equivalent of less than 30 years old, compared to age-matched control mice. Blocking ionotropic glutamatergic NMDA receptors, which regulate neuronal excitability and CA2 plus homeostasis. This article was authored by Nazreen Choudhury, Li Huachen, Lina Al-Harthy, and others. We are article.tv, links in the description below.