 In this study, the authors characterize post-acute sequelae of SARS-CoV-2, PASC, in two large cohorts based on electronic health records from the USA. They identify a broad range of PASC-related conditions which were only partially replicated across the two cohorts, indicating possible heterogeneity between populations. This article was authored by Qingxi Zhong, Yongkeng Zhong, Jie Xu, and others.