 The study presents a novel hydrogel scaffold for in vivo-catalyte regeneration, which exhibits ultra-durable mechanical properties and stage-dependent drug release behavior. The hydrogel can withstand 28,000 loading-unloading cycles, has fast-shape memory at body temperature, alleviates inflammation and regulates oxidative stress in situ, and promotes the migration of bone marrow mesenchymal stem cells into the scaffold for chondrocyte differentiation and full-thickness cartalyte regeneration.