 This study examined the factors associated with increased vaping dependence among adolescent Canadians. Daily and non-daily vapors were recruited from social media platforms and asked to complete surveys at baseline and three months later. The results showed that place of last vape purchase, pod duration, and nicotine content were the most important predictors of vaping dependence among daily users, while race, sexual orientation, and history of heart disease were the most important predictors in non-daily users. This suggests that different strategies may be needed to reduce vaping dependence among different groups of adolescents. This article was authored by Ishmit Singh, Varna Valival Punapuza, Nicholas Mitsukakis, and others.