 The early detection of respiratory pathogens and associated outbreaks is essential for effective containment and prevention of further spread. However, current syndromic diagnostic approaches are insufficiently sensitive and specific to detect all respiratory pathogens, leading to missed opportunities to identify and treat infected individuals. To address this issue, it is necessary to develop more reliable and accurate diagnostic tools that can quickly distinguish between different types of respiratory pathogens. This article was authored by Andrew W. Bartlow, Zachary R. Stromberg, Cheryl D. Glesner, and others.