 Recruitment and engagement for clinical and translational research can be difficult, particularly when targeting medically underserved and ethnically irracially diverse populations. To address this challenge, the Clinical and Translational Science Center at the University of New Mexico, UNM Health Sciences Center developed a comprehensive model that includes three key components, recruitment from within UNM to UNM-centered studies, recruitment from within UNM to community-based studies, and recruitment from outside UNM to UNM-centered studies. This model has been successful in increasing participation from underrepresented groups, especially those living in rural areas, and provides generalizable solutions to common clinical and translational research challenges. This article was authored by Andrew L. Sussman, Carla Cordova, and Mark R. Burge.