 This study aims to develop a QSAR model using the Xarein software to predict the anti-tubricular activity of tetrahydro-naftaline derivatives, resulting in a best predictive model with an R2 value of 0.8303 and CC6 value of 0.8720. The developed model helps to predict the anti-tubricular activity of new compounds through molecular docking, molecular dynamics, and admet analysis. This article was authored by Angaraj Malishankar and Teesundarajan.