 This paper proposes a new multimodal antibacterial coating that combines photothermal and photodynamic therapy, PTT slash PDT, to treat medical device-related infections caused by multi-drug-resistant MDR bacteria. The coating consists of a boron dipyromethane photosensitizer compound, DDP6, oxidized hyaluronic acid, and gelatin, which is then crosslinked with a natural polymer, polyurethane, PU. This coating exhibits excellent synergistic antibacterial performance against both susceptible and NDR bacteria. Additionally, it has good in vivo compatibility and photoacoustic imaging properties. This article was authored by Lujiao Zhang, Chen Yenhu, Meizhou Sun, and others.