 Abstract. Accumulating studies have demonstrated that non-coding RNAs, NCRNAs, functioning as important regulators of transcription and translation, are involved in the establishment and maintenance of pregnancy, especially the maternal immune adaptation process. The endometrial stromal cells, ESCs, trafoblast cells, and deciduoimmune cells that reside at the maternal fetal interface have brought to play significant roles in normal pregnancy and pregnancy-associated diseases. Here, we reviewed the up-to-date evidence on how micro-RNA, long non-coding RNA, and circular RNA regulate ESCs, trafoblast cells, and immune cells and discussed the potential applications of these NCRNAs as diagnostic and therapeutic markers in pregnancy complications. This article was authored by Xiaoxiao Fu, Yuling Li, Jinjong, and others.