 This study found that the RS-861256 allele G, RS-861256G, was associated with increased M-Ina expression and PF susceptibility in women, as well as higher risk of developing generalized lesions and resisting disease remission. The GGCCAA haplotype, which includes this allele, also increases PF susceptibility and marks higher M-Ina expression. These findings suggest that CD59 polymorphisms may play a role in T-cell signal transduction and contribute to PF development. This article was authored by Amanda Salviano Silva, Maria Luisa Petzlella and Angelica Beat Winterbolt.