 Carbopenam resistance is a major and an ongoing public health problem globally. It occurs mainly among gram-negative pathogens such as Klebsiella pneumonii, pseudomonas aeroginosa, and acenetobacter bomanii, and may be intrinsic or mediated by transferable carbapenamase encoding genes. This type of resistance genes are already widespread in certain parts of the world, particularly Europe, Asia, and South America, while the situation in other places such as Sub-Saharan Africa is not well-documented. In this paper, we provide an in-death review of carbapenam resistance providing up-to-date information on the subject. This article was authored by Francis S. Cajo and Eric S. Doncor.