 This study proposes a novel approach for treating cancer by combining two drugs, temazolamide, TMZ, and nitric oxide prodrug JSK, with sphingosine, one phosphate, S1P, molecules on their surfaces. This combination allows the drugs to be delivered directly to the tumor site while also allowing them to be released at different times. The S1P molecules enable the drugs to enter the tumor environment quickly and efficiently, while the TMZ and JSK drugs can then be released over time to maximize their effectiveness. Once inside the tumor, the drugs cause the cells to become more sensitive to chemotherapy, reducing resistance, and increasing the efficacy of the treatment. Additionally, the drugs also trigger the immune system to attack the tumor, making it easier to treat. This article was authored by Yang Liu, Lin Chui, Xiao Wang, and others.