 antifospholipid syndrome, APS, is a rare but serious condition caused by the presence of antifospholipid antibodies in the bloodstream. These antibodies can cause damage to various organs including the kidney, resulting in renal failure. This paper reviews the current literature on APS and its associated pathology, providing evidence that APS is a distinctive lesion caused by antifospholipid antibodies. The authors propose a classification system for accurately diagnosing and predicting the course of the disease. This article was authored by Muhammad Mubarak and Hamid Nasri.