 Tenzins are adhesion proteins that form focal adhesions between the extracellular matrix and intracellular actin skeleton and play a role in regulating cell motility and cytoskeleton integrity. They interact with tyrosine-phosphor-related proteins in PI3K-slash-actin-beta integrin-slash-FAK signaling pathways, and their expression varies among cancers. While some studies suggest that Tenzins are tumor-suppressive proteins, others report that they promote epithelial to mesenchymal transition and cancer cell metastasis. Recent research on Tenzins as therapeutic targets in cancers may contribute to identifying effective anti-cancer therapy. This article was authored by Marcin Nizial and Anna Pricsinix.