 The Massachusetts Medical Device Development Center, M2D2, was established in 2008 at the University of Massachusetts Lowell and the University of Massachusetts Medical School to provide support to medical device and biotech startups. M2D2 offers business planning, product prototyping, laboratory services, access to clinical testing, and ecosystem networking to help startups succeed. Over the past decade, M2D2 has expanded into new areas such as health security, point of care technologies for heart, lung, blood, and sleep disorders, and rapid diagnostics to detect SARS-CoV-2. M2D2 has also vetted over 260 medical device and biotech startups for inclusion in their programs and provided active support to over 80 firms. This article was authored by Nathaniel Hafer, Brian Buchholtz, Denise Dunlap, and others.