 And here at the ID Tech X show, hi. Hi, so who are you? Good morning. My name is Thomas Eimann. I'm managing director of the ASIS Digital Health System. Yeah. So what are you showing here? So we show here printed films with drugs and these are 3D printed drugs. So tablets. 3D printed drugs. Yes. So you can swallow this, for example, in a field. That's the active ingredient of Viagra. And the other ones? They're different ones. Yeah. Some of them are without ingredients. What's the advantage of 3D printing films? The traditional manufacturing methods are designed for mass production. So we want to produce personalized medicine. So exactly the dosage you need. So we go from one size fits all to personalized medicine. So depending on your genetics, on your age, weight, metabolism. So give you exactly the dosage you need and not what you get off shelf. Is it also a good idea to mix different ingredients in a way that mass production cannot do in normal builds? Yes. We bring different drugs into one film or one tablet. So especially very handy for old people, taking five, six pills per meal many times a day. So we bring it into one drug or two drugs per meal. So you can put the five in one pill? Exactly. And exactly the right dosage for that person? Yeah. You just need one pill? Yes. And they can swallow it the same way as a normal pill? Yes, they can swallow it the same way. It tastes the same? It could taste. So we can also bring a different taste in it, strawberry, raspberry, whatever you want. The advantage is also that the drugs could have different release times. So we don't mix the drugs. So the drugs are independent. So one drug works in two hours and the other one in four hours. Inside one pill? Yes. So that's the standard way that pills work, right? That's the benefit of the drug combination we can produce with 3D printing. How? The pharmacokinetics, it's nothing we developed. That's already there. But we bring the different drugs into one pill, which is not possible with the mass production. They make millions of the same pill? Exactly. So 3D or the 2D printing is the key for us to make personalized medicine. So you can do it for food supplements? We can do it as well for food supplements, yes. That's a big market, right? It's a big market but also for pharmaceuticals. So keep in mind that, for example, a very known blood thinner, it only exists in a free milligram tablet. If you look around, all of the attendees here... Need the blood thinner? No, but that's different. So you and me, maybe of the same shape, are taking a girl of 50 kilograms. You can imagine that we both do not need the same pill. And this depends on many other drugs as well. But this is reality. This is a big headache for doctors, right? They're thinking like, you should get this, that. But actually you have to calculate based on how big people are. And it would be better if it could be precise. But this vital data is already available in many indications. So is it weight or is it your liver function, your kidney function or whatever? And also these algorithms you may need are, many of them are developed already. But the drugs are not there. So what we do, we translate the knowledge out of the diagnostic we already have into therapy. Can you show the machine how it looks? Yeah, you can... There? Yeah, it's on the floor. This is a 3D printer for pills. So that's a pony pill. That's the 2D printing. Is roll to roll? Here is the... What is that? It's a 2D, 3D printing. That's the 2D printing machine. It's a big machine. It's a big machine, but it's also until you pack it. So it's everything in one machine. And that's a pony pill. So with multiple drugs into one. That's also a pony pill. A pony pill. And what is this? This is oral dispersable film. So you can put it in the mouth. And then what happens? It dissolves and the drug can be immediately absorbed. So this is very handy for kids and for old people. We don't like to swallow pills. Exactly. We don't have all the same stuff? What do you mean have all the same stuff? When you swallow a pill, it goes further down the system, right? Yeah, but here it's immediately absorbed because it dissolves. Also the substrate dissolves. And the drug itself can immediately be absorbed. Did you say that the whole thing is swallowed? Yeah, no, it's dissolved. So you don't swallow anything? It dissolves on your tongue. And then there's nothing left? No. It's not paper you have to throw out after? No, nothing is left over. So this is a future of medicine? It's a little piece of QR code? This is a very well-known monographed oral dosage form. But the traditional method was that the drug was incorporated or embedded in the substrate. And then it's already designed for mass production. What we do, we print the drug on the substrate. It's similar like an inkjet, you know, from printing paper. So instead of ink, you print the drug? The drug is in the ink. And what we do is not only developing the printers. We do the formulations for the printable inks. And for the 3D printing, it's a filament. So we embed the drug in the filament. The filament will be melted and then built into a tablet layer for layer. Do you see it in the film? What is this? This is the 3D printer. This is the polypill? And these machines right here? That's just a 2D printer? Now it's printing a 3D printer. Is it 100% safe? Yes. Is it FDA approved or what's it called? No, it's not yet FDA approved. But it's GMP compliant. So GMP is good manufacturing practices. So that's the regulatory we have to obey across the world. FDA is the USA, right? FDA, that's the authorities in the US. But it's the same in Europe? It's completely similar. It's not the same, but it's almost the same. So how soon you will be FDA and European FDA approved? Yeah, we hope end of the year. Because it's new? All this? It's pretty new. But it looks like big machines. Is it the same machines you would use to do all this other 3D printing stuff? Or is it custom made for this? No, no, no. Our customers will be hospitals and pharmacists. So we're aiming for desktop printers. So they will buy the printer from you? Or do you print the drugs for them? No, no. We want to enable them to print it. So the hospitals and the pharmacists will print. Wow. Is this also going to revolutionize somewhat the R&D and research in medicine somehow? Yeah, of course. How can it change that? Clinical trials can be done much more quickly with digital printing. So it's also interesting for pharma companies. And of course it could change the supply chain because nowadays drugs are bought and sold by wholesalers. So if it's printed by hospitals and pharmacists themselves, this could change the supply chain. Because a normal way to make a pill, you have to do a mold for it or something? It's a tablet press. It's pressed? It's pressed. An extended pressing thing? Yeah. But that's fast. They don't have a machine, they can do quick samples. Yeah, but this is mass production. What we are aiming at is precision medicine. So that's, yeah, individualized. It's not for mass production. So where are you based? Between Stuttgart and Munich in Germany. All right. What do you think about the IT Tech Act show? It's very interesting. So we're kind of an exotic company. But yeah, we're looking around because we're also looking for partners and looking for, yeah, let's say the newest technical equipment. Who's your partner going to be? What kind of partner you need? We need partners in the IT field. And so the formulation, so the pharmaceutical development and also the printers we do on our own. But also we need partners in the app for the printers. We are coming from the farmer side. So yeah, of course we're looking for technical experts also in the printing part. Farmer is big. Yeah. It's a big industry, right? Yeah. Don't they have a lot of interest right now? What are you doing? There is a big interest but it's also a very conservative industry. So it takes time to change. Do you have competitors? No. There are. There are companies and we know in the UK and in Asia. But you're the best. Yeah. So we're coming from farmer. We have more than 25 years experience all of our team and farmer. And different farmer companies or what? Farmer companies, development of pharmaceuticals and so yeah we hope we're still ahead of the others. So in the farmer world and in the state of science right now we have a lot of diagnostics. Yes. And it's possible to know a lot of things but they're not put into practice. We don't know everything, right? The doctors don't know everything? We don't know everything but we have a big know how in diagnostics and it's coming more data every day. And what we want to use, we want to use this data out of diagnostics and translate it into therapy. And of course the doctors have to know all these algorithms or vital data. But if the doctors are provided with this data giving him the opportunity to calculate then the exact dosage, it was helped the patients a lot. So personalized medicine is putting the patient in the centric, giving him exactly the dosage he needs. So for sure in the way that doctors work today and in the way they have diagnostics today, there's a lot of potential in what you're doing already? Absolutely. And still the doctor is the one deciding on the dosage. So he is the one deciding giving the patient the right pill, the right ingredient, the right dosage. And is it possible to use AI for this? Yes, of course to developing the algorithms if we know which factors are important for the effectiveness of the truck. So AI would help a lot to develop the right algorithms. Because you input the weight, you input the size, you input what? The metabolism, so the kidney function, the liver function, whatever. And even blood tests and even environmental circumstances, habits for example. Is it possible that something like a smartwatch that would have maybe a humidity sensor, heart rate sensor, all this could be incorporated? Yes, for some indication it would help a lot. And then automatically it would print out, customize, exact. But there's still a lot of margin for improving the understanding of exactly who needs what, no? Of course, of course still. But is there like a requirement to do it differently now that you can dose everything precisely? Does the industry need to understand something differently now, maybe potentially? Today we have just, yeah, the Dosage Forms Pharmacos Produce, so 10 milligram, 10, 20, 30. And we are aiming at to get you 8 or 12 milligram or 45, whatever you need. And so are you having a speech here? Yes. What you will talk about? I will talk about personalized medicine and that digital printing is the key to that. So with digital printing we are able to produce personalized medicine. You have some examples also? You just talking about the pizza for example? Yeah, you know, everything in daily life today is getting more and more individualized again. So we started from individualized getting into mass production and now everything is going back into personalization and we want to do that in pharma. Because, for example, pizza people can choose what they want on it, right? Exactly. But for the drug, yeah, you are forced to take what you get off shelf. And we want to make the patient able to get the medicine he exactly needs. To get, let's say, as much effectiveness but to lower the side effects. And we have in many countries already the so-called pay-for performance in place. So that only the drug will be reimbursed, that works, and have less side effects. This is what we are aiming at with personalized medicine. It's a huge problem in the industry of pharma with the people who get the wrong medicine. Yeah. And who sadly die or get sick. We have false medication in hospitals. Huge amount of people, right? Yeah. So this also would help a lot. So as you see here, this is a barcode where all the information is included. Name of the patient, dosage. And also gives him a recommendation what he should not drink or take together with this substrate. I'm just thinking, it's just a short idea, but maybe because you want to prevent bad medication, what you call it, false medication. You want to maybe, for example, give them a small dose and immediately measure the effect and then increase the dose so you can have the pills increasingly get more of this thing. Yeah, it's much more... And then you can know exactly how much they need for, for example, somebody doing... No, it's much more easier. If a patient comes into hospital, for example with Parkinson's, today they test every day giving, yeah, increase the dosage, but only with, yeah, let's say the standard pills they have. Here, with this possibility, you can precise giving not only the one cream or more, it's maybe 10, it's just a 10th or whatever. So it's much more easier to tight rate this high for the patient. Easier to reach the right dosage. The standard therapy right now giving 1 milligram, 2 milligram, and then they go up to maybe 5 or 10. Here, you can much more do it precisely. And if you look for pediatrics, for example, this is for children. The hospitals, they do it right now manually so they destroy the standard pill and then try to make an individual dosage. But of course, it's a lot of work and yeah, we have a lot of mistakes. Because a baby is a small human being. Yeah. You need to have exactly the right amount. Yeah. And what about people that have maybe let's say drug addicts that try to get off the drugs. Yeah. And maybe they also need to slowly get into a certain way of getting off their addiction. Yeah. Of course, this is also very handy for, yeah, all kind of drugs like cannabis or whatever. But it would be nice to have it in combination with some kind of way where people maybe can test themselves at home to check after the pill, to check the results without having to go back to the hospital every time to check or maybe, I don't know, if that makes sense. Yeah, it depends. It has to be controlled by the experts. All right. Cool. All right. Thanks a lot.