 Ultra-high-performance concrete, UHPC, is a high-tech cementitious material with superior mechanical and durability properties compared to conventional concrete. However, its cost and environmental impact are higher due to the high content of cement and silica fume used. This study aimed to design and produce UHPC using local fly ash available in Colombia through numerical optimization based on design of experiments, dough, and multi-objective criteria. The results showed that compressive strength values of 150 mPa without any heat treatment can be achieved despite the low quality of local fly ashes in Colombia.