 MSCs have shown promise in treating various diseases, but there are still some limitations that need to be addressed. Recently, priming strategies have been developed to enhance the therapeutic potential of MSCs. These include cytokine and growth factor priming, hypoxic priming, pharmacologically induced priming, biomaterial primed MSCs, and other priming methods. This article was authored by Nadia de Caso Narona, Amanda Mizukomi, Carolina Calliari Oliveira, and others.