 Dear students, in this topic, we shall discuss the tropic hormones of adeno-hypophysis in detail. The tropic hormones are the hormones which act on other endocrine tissues and regulate their secretory activity. Adeno-hypophysis that is an anterior pituitary gland produces four tropic hormones. Adeno-Carticotropic hormone ACTH, thyroid stimulating hormone TSH also called thyrotropine stimulating hormone and leutinizing hormone LH and follicle stimulating hormone FSH. The adeno-Carticotropic hormone or ACTH is a peptide hormone that comprises a single chain of 39 amino acids. Its principal function is to regulate the secretion of corticosteroid hormones by the cortex of adenyl gland. It also stimulates the secretion of androgens by adenyl cortex. Another major role of adenyl cortex is that the glandular tissues that is the zona fasciculata or zona reticularis maintain the size of adenyl cortex. It also stimulates the lipoprotein uptake by the adenyl cortex. These adenyl cortex cells have a major function which is cholesterol synthesis so that they can make corticosteroids. The lipoproteins and the requirements for the cholesterol synthesis have an uptake of the lipoprotein ACTH and as a result it promotes the cholesterol and steroid hormones synthesis. In many other organisms, ACTH also plays a role in circadian rhythms. Thyrotropin or TSH thyroid stimulating hormone is a glycoprotein. Its production is stimulated by the thyrotropin releasing hormone TRH from the hypothalamus. TSH is secreted throughout life but its levels are particularly high during fast growth and development. This hormone, TSH acts on the follicular cells of thyroid gland and helps to maintain their size. It also controls the rate of secretion of thyroid hormones thyroxine that is called T4 and triiodothyronine that is called T3. These hormones, T3 and T4 in turn control the rate of metabolic reactions in the body. The leutinizing hormone and follicle stimulating hormone collectively called as gonadotropin are glycoproteins. They are released under the influence of gonadotropin releasing hormone GNRH from the hypothalamus. Both these hormones work together in the reproductive systems of both males and females. These hormones act on gonads and control the growth of ovaries and testes. They also stimulate the secretion of gonadal hormones. FSH stimulates the development of ovarian follicles and regulates spermatogenesis in males. Leutinizing hormone stimulates the production of estrogen and progesterone by the ovary. This hormone also causes ovulation that is because of the action of leutinizing hormone and also acts to in the formation of carpus luteum. In males the leutinizing hormone is also called as ICSH that is interstitial cells stimulating hormone that stimulates testosterone production by the leading cells of testes.