 This study proposes a novel collagen deep learning, collagen DL, classifier for predicting disease-free survival, DFS, and overall survival, OS, in stage 2 to 3 colon cancer, CC, patients. The collagen DL classifier was found to be significantly associated with both DFS and OS. Additionally, it was shown to improve the prediction performance when combined with other clinical factors. Furthermore, high-risk stage 2 and 3 CC patients with high collagen DL classifier had better responses to adjuvant chemotherapy. This suggests that the collagen DL classifier may be useful for identifying patients who are likely to benefit from adjuvant chemotherapy. This article was offered by Wei Jiang, Huai Ming Wang, Wei Xing Chen, and others.