 Pemphigus is a rare autoimmune-blistering disease that affects the skin and mucus membranes. Despite recent advances in treatment, Pemphigus is associated with high patient mortality and has a significantly negative impact on patient's quality of life and mental health. Validated scoring systems to accurately measure Pemphigus severity are vital for the monitoring of disease activity, evaluation of treatment efficacy and trialing, comparison and introduction of new treatments. This article reviews the existing scoring systems for Pemphigus and their validation studies and proposes a future area of research regarding global assessments for simplistic scoring of Pemphigus severity. This article was authored by Dabi Boucher, Anna Wilson and Dede F. Murrell.