 The CTSA consortium has developed a framework to assess the adaptability of its member institutions during the COVID-19 pandemic. This framework includes a local adaptation model which examines the interconnectedness of CTSA programs and services, and the impact of the pandemic on their operations. The results of this study have revealed several key insights into the adaptive capacity and preparedness of CTSA hubs, including the importance of collaboration between CTSA hubs and other stakeholders, the need for flexible funding sources, and the necessity of maintaining strong relationships with external partners. These findings can be used to inform future efforts to strengthen the core service models, strategies, and foster innovation in clinical and translational science research. This article was authored by Boris B. Volkov, Bart Ragon, Jamie Mihoko Doyle, and others.