 The COVID-19 pandemic has had a significant impact on the ability of CTSA TL1 trainees and KL2 scholars to conduct their research. Lack of access to research facilities, clinics, and human subjects has been the most detrimental effect, while KL2 scholars have also experienced difficulty accessing team members and being unable to work in person. In order to maintain research productivity, TL1 trainees have shifted to writing and thinking more, while KL2 scholars have relied heavily on virtual connections with colleagues and have shifted to research activities not requiring laboratory or clinic settings. To mitigate the effects of the pandemic, strategies such as time management, virtual connections, and shifting to non-lab clinic-based research have been employed. This article was authored by Wayne T. McCormick, Miriam A. Bredella, David H. Hingbaugh, and others.