 Revealing the mystery of the brain is the larger frontier in science. The human brain is a very sophisticated neural network containing 100 billion neurons that generates emotion, perception, and so on and so forth. Brain scientists at Fudan University have long been exploring fundamental principles of brain functioning with a special emphasis on bench-to-bed work by forging a closer and interactive collaboration between basic and clinical research. Brain disorders such as drug addiction is a global public health issue. That causes a very serious problem, not only in healthcare but also in social stability. The treatment for drug addiction is extremely challenging given the frequent relapse. Simply due to the exposure to drug-related environmental cues, we are now trying to develop a novel strategy for better treatment of relapse. We have first established a mouse model of cocaine addiction by ejecting cocaine into the belly and kept these mice in this very well-designed environment referred as to drug-related environment. When these mice were treated by a process called extinction learning, that is to let these mice be repeatedly exposed to drug-related environment but without providing cocaine, these mice show decreased repress. Our major finding is that the effect of extinction learning could be enhanced by cavodilo, a drug targeting congestive heart failure. And this important finding strongly suggests cavodilo and other relevant drugs could be developed as new potential medications along with existing behavioral therapies to reduce the occurrence of relapse dramatically. On the other hand, we also endeavour to contribute to the restoration of neural functions. Eye diseases such as retinitis pigmentosa could eventually lead to blindness by killing all light response cells in the retina. In collaboration with Material Science at Fudan University, we recently developed light sensitive titanium oxide nanowires that serve as artificial light-responsive cells in the eye. When transplanted into the eyes with retinitis pigmentosa, these nanowires could generate electric currents that activate not only the neurons in the retina but also in the neurons in visual cortex, a hyacinth of vision. When put into a light-dark box, these mice would preferentially stay in the dark side of the box, a light-driven avoidance behaviour in mice. Strongly suggest that these mice, once blinded anymore, are now able to perceive light. These results, though preliminary, could use to be a potential new treatment option for people at the risk of long-term visual degeneration. Brain scientists at Fudan University will do much more efforts to improve the treatment of brain disorders by strengthening the close and interactive collaboration between clinical and basic research. In the China brain project, a nationwide effort to push brain research forward in clinical, basic and brain-inspired intelligence aspects in China, we have been playing in the will to continue to play a crucial role. Thank you very much.