 The study examined the concept of U2 in Tanzania by developing a five-factor measurement scale and validating it with adolescents. The results showed that U2 is a collective asset associated with higher levels of reported resilience in both orphan and non-orphan adolescent populations in Tanzania. Furthermore, promoting U2 may be an effective universal public health prevention approach. This article was authored by Megan Cherwick, Ronald E. Dahl, Daphna Rubin, and others.