 Incredible new video shows stem cells escaping from hair follicles, which could provide insight on a new, potentially reversible mechanism of hair loss. We'll show you the videos and explain why this is so important on this episode of Lifespan News. Stem cells contribute to tissue regeneration, and they are also thought to play a role in age-related decline. So much so that stem cell exhaustion is one of the hallmarks of aging. These stem cells reside in compartments in various tissues. In the hair, the stem cell compartment, known as the bulge, is adjacent to the hair follicle. It is extremely hard to monitor stem cell activity in live animals over time, yet that is exactly what the researchers of this study have achieved using non-invasive imaging techniques based on lasers. By anesthetizing the mice and putting them inside the imaging device, they were able to observe and record the process of stem cells escaping their compartment. As you can see in this video, researchers watched as escaping stem cells changed their shape and shot out of the compartment as if squeezing through invisible holes. These holes are most likely structural abnormalities in the membrane. The researchers hypothesized that aging somehow harms the structural integrity of the membrane, but this phenomenon requires further examination. The rogue stem cells escape to the dermis, which is the lower layer of skin. Once there, they remain stem cells and seem to be doing quite well in the new environment. However, this might not be a good sign, as stem cells are known to contribute heavily to tumor genesis. The authors call for more research into the role the escaping stem cells might play in the development of cancer. Sticking with hair loss, though, the researchers studied both young and old mice. In young animals, the stem cell compartment was well-defined, and cells were restricted to their rightful place. In many older mice, however, the researchers noticed the shrinkage of the hair follicle and compartment. The shrinkage was even more pronounced when the compartment showed signs of stem cell escape. The researchers looked for proteins that were down-regulated in the follicles that experienced stem cell escape, zeroing in on two transcription factors. These identified proteins are indeed known to regulate cellular adhesion as well as the integrity of the extracellular matrix. The scientists then created genetically modified mice with both of these proteins knocked out and found that they demonstrated massive hair loss. Although it wasn't studied here, researchers suggest that up-regulation of these proteins could potentially alleviate age-related hair loss, which could be a huge breakthrough in the eyes of many. These findings seem to support an idea that has been gaining popularity in the longevity field, that the integrity of the extracellular matrix might be a much more crucial factor of aging than previously thought. Not only does this paper reveal a new, potentially reversible mechanism of hair loss, but it also pioneers a non-invasive imaging technology that enables scientists to observe aging on the cellular level in live animals. This research could potentially help us understand more fundamental mechanisms of aging. Research is continuing, and when there's more updates, we'll bring them to you here, so please subscribe so you don't miss out. I'm Ryan O'Shea, and we'll see you next time on Lifespan News.