 the COVID pandemic and the COVID crisis really impacted everything, our daily life, our work life and also clinical trials. And I think all academic centers and also all other trial centers try to keep patients as good as they could in the clinical trials, treated them per protocol and a maximum of safety. However, many trials stopped recruitment or were not centers were not initiated during the COVID crisis. Resources were put on other infrastructures at need so that the progress and the power and the speed of the progress we made is definitely slowed down when not shortly interrupted. And we have all together to work on to keep that going and this is our all interest in sense of our patients.