 This study investigated the potential use of circulating cell-free DNA, CFDNA, methylation as a diagnostic tool for colorectal polyps. The researchers used a genome-wide analysis to identify differentially methylated CPG sites between colorectal polyp and normal tissue samples. They then narrowed down their list to four CPG sites which were most likely to distinguish between the two types of tissue. These four CPG sites were then tested in a plasma sample set and found to have high accuracy in distinguishing between colorectal polyp and normal tissue. Furthermore, one of these CPG sites, CG27541454, was also found to be hypermethylated in colorectal cancer compared to normal tissue. This suggests that this site may be useful as a non-invasive biomarker for early detection of colorectal cancer. This article was authored by Qing Xiaofang, Ziming Yuan, Han Qinghu, and others. We are article.tv, links in the description below.